Currently, P-15L Bone Graft is only available for use in this trial. It is believed that fusing the bones will help in relieving your pain and loss of function. This research study has been designed to determine if the use of P-15L Bone Graft is as good at fusing bones surrounding your damaged disc as using your own bone and possibly donor bone following a spinal fusion surgery.
#IFACTOR ORTHO TRIAL#
The ASPIRE trial is a new clinical study being conducted at 30 locations throughout the United States. This unique combination creates a surface-bound “Attract, Attach, Activate” mechanism of action that enhances the body’s natural bone healing process. P-15L is the only biologic bone graft made of a synthetic small peptide (P-15) that is attached to an anorganic bone mineral (ABM). The P-15L Bone Graft triggers your body’s natural cellular bone healing response and then it will resorb after healing has occurred. The carrier is a collagen putty made from bovine (cow) tissue that holds these components together. P-15 peptide is a synthetic (man-made) segment of collagen (main component of the tissues in your body) that is responsible for natural cellular attachment and activation. Calcium phosphate is a mineral found in your own bones. P-15L Bone Graft is a bone graft substitute that contains calcium phosphate particles and P-15 in a carrier. In recent years, other bone graft substitutes have been invented to help fuse the bones including P-15L, a new product being tested in the ASPIRE trial. One of these can include donor bone (allograft). When there isn’t enough of your own bone, other materials can be used to help fuse the bones. Because your body is already familiar with the bone, it creates the optimal environment for a healthy bone fusion 2. This bone is taken from your own body and is the most popular type of bone graft because it has no risk of disease transmission, and your body accepts the transplant well. The gold standard is to fuse the bone surrounding the damaged disc using your own bone (autograft bone). If those treatments do not provide relief, you may be referred to a surgical procedure, such as a fusion, to relieve the pain.ĭuring a fusion, the surgeon will fuse (connect) the bones surrounding your damaged disc. In order to treat the pain associated with DDD, physicians typically start to treat with exercise, physical therapy, pain medications and more. When all that happens, the discs change from a supple state that allows fluid movement to a stiff and rigid state that restricts your movement and may cause pain 1. As you age, the discs can lose flexibility, elasticity, and shock absorbing characteristics. Degenerative disc disease (DDD) and treatment optionsĭegenerative disc disease (DDD) occurs when your discs degenerate (break down) and cause pain.
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